Allopurinol in patients with impaired renal function.
نویسندگان
چکیده
منابع مشابه
Allopurinol treatment and its effect on renal function in gout: a controlled study.
Fifty-nine patients with primary gout were treated with either a combination of colchicine and allopurinol or colchicine alone. Assessments of renal function over 2 years revealed a statistically significant fall of glomerular filtration rate an urine concentrating ability in those receiving only colchicine. The renal function of patients given allopurinol did not change. Treatment with allopur...
متن کاملWithdrawal of allopurinol in patients with gout.
The xanthine oxidase inhibitor allopurinol effectively lowers the plasma level of uric acid and the drug has become widely used in the treatment of gout, especially in patients with renal failure, uric acid calculi, or intolerance to uricosuric agents (Scott, Hall, and Grahame, 1966). Various theoretical complications of treatment have been considered from time to time, such as possible incorpo...
متن کاملAllopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events.
Allopurinol is the mainstay of urate-lowering therapy for patients with gout and impaired renal function. Although rare, a life-threatening hypersensitivity syndrome may occur with this drug. The risk of this allopurinol hypersensitivity syndrome (AHS) is increased in renal impairment. The recognition that AHS may be because of delayed-type hypersensitivity to oxypurinol, the main metabolite of...
متن کاملاثرات درمانی آلوپورینول بر عملکرد بطن چپ در بیماران مبتلا به نارسایی مزمن قلب
Introduction & Objective: Heart failure that is a major health problem with increasing incidence with the aging of the population often occurs as a result of ischemia and coronary artery disease. Allopurinol can protect the ischemic heart muscle and improve the use of energy during myocardial ischemia. The aim of the present study was to evaluate the effects of allopurinol on the left ventric...
متن کاملEffects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial.
OBJECTIVE To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function. METHODS Subjects (n = 1,072) with hyperuricemia (serum urate level > or = 8.0 mg/dl) and gout with normal or impaired (serum creatinine level >1.5 to < or = 2.0 mg/dl) renal function were r...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 25 6 Suppl شماره
صفحات -
تاریخ انتشار 1966